Reduction of venous pressure during the resection of liver metastases
compromises enteric blood flow: IGFBP-1 as a novel biomarker of intestinal
barrier injury
HV Barbeiro, Machado MA, HP Souza, FP Silva, MC Machado
OBJECTIVES: Disruption of the intestinal barrier and bacterial translocation commonly occur when intestinal
blood flow is compromised. The aim of this study was to determine whether liver resection induces intestinal
damage.
METHODS: We investigated intestinal fatty-acid binding protein and insulin-like growth factor binding protein
levels in the plasma of patients who underwent liver resection.
RESULTS: We show that liver resection is associated with significant intestinal barrier injury, even if the Pringle
maneuver is not performed.
CONCLUSION: We propose the use of insulin-like growth factor binding protein-1 as a novel biomarker of
intestinal damage in such situations.
Abstract
Reduction of venous pressure during the resection of liver metastases
compromises enteric blood flow: IGFBP-1 as a novel biomarker of intestinal barrier injury
HV Barbeiro, Machado MA, HP Souza, FP Silva, MC Machado
Clinics. 2017;72(10):645-648
https:// 10.6061/clinics/2017(10)10
OBJECTIVES: Disruption of the intestinal barrier and bacterial translocation commonly occur when intestinal
blood flow is compromised. The aim of this study was to determine whether liver resection induces intestinal
damage.
METHODS: We investigated intestinal fatty-acid binding protein and insulin-like growth factor binding protein
levels in the plasma of patients who underwent liver resection.
RESULTS: We show that liver resection is associated with significant intestinal barrier injury, even if the Pringle
maneuver is not performed.
CONCLUSION: We propose the use of insulin-like growth factor binding protein-1 as a novel biomarker of
intestinal damage in such situations.